BiOS provides contextualized one-stop solutions for images in biology and medicine from processing, segmentation, analysis to new discoveries. We have developed auto-segmentation methods to produce organelle masks, post-processing tools to separate individual organelles, and systematic analysis pipelines to identify organelle morphologies and organizations.

We have applied these tools on soft X-ray tomograms (SXT) for the fast and accurate generation of insulin vesicle, mitochondrion, nucleus and whole cell masks, and for the characterization of both molecular densities and spatial arrangements of insulin vesicles and mitochondria to reveal the impact of external treatments on subcellular structures.

Recently, we are processing through fluorescent movies and cryo-electron tomograms (cryo-ET) to explore velocity distributions, packing properties, and neighborhoods of different organelles under different physiological conditions. Our platform is expected to extend to other image types including MRI, CT, PET-CT, etc..